Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications
نویسندگان
چکیده
منابع مشابه
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
The data for this study were provided by the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA). The BSRBR-RA is funded by a grant from the BSR. The BSR currently receives funding from AbbVie, Pfizer, Roche and UCB and in the past from Swedish Orphan Biovitrium and Merck. This income finances a wholly separate contract between the BSR and the University of M...
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The complement system is the most important biochemical cascade in the blood for the recognition, opsonization, and elimination of foreign materials. To date, the leading causes of death in the United States include cancer, cardiovascular and neurodegenerative diseases, and diabetes. New treatments are urgently needed to treat these devastating diseases and nanotechnology potentially provides n...
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The complement system is an essential element of the innate immune response that becomes activated upon recognition of molecular patterns associated with microorganisms, abnormal host cells, and modified molecules in the extracellular environment. The resulting proteolytic cascade tags the complement activator for elimination and elicits a pro-inflammatory response leading to recruitment and ac...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2021
ISSN: 1538-7933,1538-7836
DOI: 10.1111/jth.15082